Trying mental and stress-relief activities such as. Although allergic reaction wasnt reported in studies of Femara, it can still happen. However, be sure to take the dosage your doctor prescribes for you. Its meant to be taken as a long-term treatment. Your doctor will explain how you should take Femara, such as how much to take and how often. How does Arimidex work? Weight gain. Femara may cause reduced bone mineral density (weakened bones) in some people. To find out how often these side effects occurred in clinical studies, see the drugs prescribing information. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. But if they become more severe or dont go away, talk with your doctor or pharmacist. Instead, Femara is a hormone therapy. Tell them about all prescription, over-the-counter, and other drugs you take. In other words, it takes about 2 days for your body to get rid of half of a Femara dose. Such drinks and foods may worsen hot flashes. No, the Food and Drug Administration (FDA) hasnt approved Femara for use in bodybuilding. Swelling from Femara usually occurs in your arms, feet, hands, or legs. But its not known how often this occurs in people using Femara. Its available in one strength: 2.5 mg. For information on the effectiveness of Femara, see the Femara uses section below. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Headaches were a common side effect in studies of Femara. For hot flashes, you should first try to relieve symptoms through lifestyle changes. Maintaining a moderate weight. Swelling caused by Femara typically occurs in your arms, feet, hands, or legs. When will I ovulate after taking letrozole? It may also be used when someone is premenopausal and having treatment to stop the ovaries working (temporary menopause). 2005-2023 Healthline Media a Red Ventures Company. Here are some common questions about taking Femara tablets. Here are answers to some frequently asked questions about Femara. (Letrozole is the active drug in Femara.) Letrozole lowers the levels of the female sex hormone oestrogen in the body. Generally it takes four to five half-lives for a drug to be eliminated from the body, so in the case of Arimidex this would be 150 to 300 hours, or six to 12 days. People being treated for primary breast cancer will usually take letrozole for five to ten years. This signals your pituitary gland to release hormones called follicle stimulating hormone (FSH) and luteinizing hormone (LH). Sometimes your doctor may recommend that you take a higher dosage of Femara, such as 5 mg or 7.5 mg daily for 5 days. What are the mild side effects of Femara? Because these drugs work in the same way, their side effects are very similar. But if they become bothersome, talk with your doctor or pharmacist. However, if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room. No, Femara isnt a chemotherapy drug. They work by lowering estrogen levels within your body, which helps stop the growth of breast cancer. Your doctor can recommend treatment options other than Femara. Learn about side effects, warnings, dosage. If you miss a dose, do not take a double dose the next day. Like most drugs, Femara can cause an allergic reaction in some people. Femara is used in the following ways for early HR+ breast cancer: Femara is used in the following ways for advanced breast cancer thats either HR+ or whose hormone receptor status isnt known: * Sex and gender exist on spectrums. Femara has been found effective for treating certain types of breast cancer. This stops estrogen from being able to stimulate breast cancer cells to grow and multiply. With early breast cancer, the cancer hasnt spread out of either your breast or the lymph nodes in your armpit. These effects are called interactions. For this use, youll usually take the drug for 5 years following surgery to remove the cancer. Chemotherapy describes traditional drugs used to treat cancer. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. You should not become pregnant or breastfeed for at least 3 weeks after your last dose of Femara. And let your doctor know if you have more questions about these medications. Letrozole is usually taken for 5 years, but may be recommended for up to 10 years depending on individual circumstances. You may take Letrozole with or without food. Learn. Certain drugs, such as paroxetine (Brisdelle, Paxil), are used to treat hot flashes. Femara can be an effective treatment option for certain types of breast cancer. In studies, increased cholesterol levels were one of the most common side effects among people taking Femara. But its not known if drinking alcohol after youre diagnosed with breast cancer can make your cancer worse or more likely to come back after treatment. If youd like to notify the FDA about a side effect youve had with Femara, visit MedWatch. https://www.drugs.com/pro/letrozole.html, Letrozole (Femara) Breast cancer now. Breast cancers that are stimulated by hormones, such as estrogen, are called hormone receptor-positive (HR+). Mild side effects of Femara can usually go away within a few days or a couple weeks. Your doctor will usually recommend using an ovulation predictor test to help you know when youre about to ovulate. They can tell you about other medications that may work well for you. You can take your dose at any time of the day. * In this article, we use the term female to refer to someones sex assigned at birth. But make sure you talk with your doctor or pharmacist before taking any new medications with Femara. Treatment will be taken over five consecutive days. Femara can stay in your system for several weeks after your last dose. Breast cancer occurs when breast cells grow rapidly and out of control. Hormone therapy may also be used to treat hot flashes. After youve gone through menopause, your ovaries no longer produce estrogen. For details about how side effects for these drugs compare, see the Arimidex vs. letrozole section of this article. But you wont be able to notice it working in your body. To help make sure that you dont miss a dose, try setting a reminder on your phone. Not all side effects are listed above. It only has these risks if its taken when youre already pregnant. Letrozole works by decreasing the amounts of these hormones in the body. Femara is FDA-approved for adjuvant treatment of early breast cancer thats hormone receptor-positive (HR+). You should always consult your doctor or another healthcare professional before taking any medication. Learn the signs and symptoms of metastasis, how you can make yourself as comfortable as possible, and tips for managing end-of-life symptoms. If you miss a dose of Femara, take it as soon as you remember, unless its almost time for your next dose. ChildrenUse and dose must be determined by your doctor. So, dont be afraid to ask questions or offer feedback on your treatment. As a type of hormone therapy, Femara works by lowering estrogen levels in your body. If your doctor thinks Femara has stopped working for you, talk with them about whether stopping treatment could be beneficial for you. And some may be easily managed, too. Serious side effects from Femara arent common, but they can occur. What Types of Breast Cancer Have the Highest Recurrence Rates? Taking a Break From Letrozole Therapy After Breast Cancer. But some healthy cells in the body also quickly multiply. This helps slow the growth and spread of cancer thats encouraged to grow by estrogen. The most common cause of ovulation problems that result in infertility is polycystic ovary syndrome (PCOS). But Femara is also sometimes used to treat infertility that doesnt have an obvious cause. . Keeping cool with a fan or removing layers of clothing during hot flash episodes. Below are examples of off-label uses for Femara. One way your doctor will monitor your bone strength is by measuring your bone mineral density. your doctor may . Those that have been reported with Femara include: To learn more about each of these side effects, see Side effects explained below. Be sure to always take Femara exactly as your doctor recommends. Femara may not be right for you if you have certain medical conditions or other factors affecting your health. For more information about this use of Femara, see the section Off-label use of Femara for infertility below. I was prescribed Letrozole about 6 weeks before my operation, bilateral mastectomy with implants. headache*. In any case, your doctor will recommend how long to keep taking Femara. Your doctor will determine the best dosage to fit your needs. They can give you tips on how to deal with any side effects that may be bothersome. You should take Letrozole at about the same time each day. Femara isnt currently approved to treat infertility in females. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Alcohol isnt known to interact with Femara. Letrozole is approved to be used alone or with other drugs to treat: Breast cancer in postmenopausal women who have any of the following types of breast cancer--. After menopause, your body produces less estrogen, which can weaken your bones. Femara tablets contain the active drug letrozole. Based on when your period begins, your doctor will advise you when to start treatment. Liver problems. Adjuvant treatment of breast cancer is treatment thats taken to reduce the risk of the cancer coming back after surgery. It is usually used when you have been through a natural menopause. Clomid has been discontinued, but generic versions of clomiphene are still available. My doctor said Femara may cause hot flashes. Talk with your doctor if you have bothersome spotting while taking Femara. If you have questions about using Femara, talk with your doctor. If you have questions or concerns about changes in your weight, talk with your doctor or pharmacist. After five years, last September, my GP said that I should stop takingt the Letrozole, but could not answer any of my questions, e.g. You might take a look at the Calling Long Term Survivors thread, I believe there's a couple of women who have been on it for 4+ years. For example, they may order imaging tests to see if your cancer tumors are shrinking. Talk with your doctor about your health history before you take Femara. Different interactions can cause different effects. The generic is considered to be as safe and effective as the original drug. Femara isnt approved to treat endometriosis. Learn more about some of the side effects that Femara may cause. Other interactions can increase side effects or make them more severe. If you have breast cancer, you may be wondering if it's safe to practice yoga. G n' J FormerMember over 6 years ago in reply to Dreamthief Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms. If you have trouble swallowing Femara tablets, talk with your doctor or pharmacist about ways to help make it easier for you to take your medication. Femara is a type of hormone therapy used to treat breast cancer. Femara and clomiphene are both used to induce (cause) ovulation in females* who are having trouble becoming pregnant. To learn about other mild side effects, talk with your doctor or pharmacist, or read Femaras prescribing information. (Off-label use is when a drug thats approved for one condition is used to treat another.) As with all medications, the cost of Femara can vary. Talk with your doctor or pharmacist if youre taking tamoxifen or any products that have estrogen in them. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. This means that chemotherapy can affect both cancer cells and healthy cells. If you have questions about using Femara to treat infertility, talk with your doctor. If you no longer need to take Femara and have leftover medication, its important to dispose of it safely. Our website services, content, and products are for informational purposes only. With early breast cancer, the cancer hasnt spread out of either your breast or the lymph nodes in your armpit. Breast Cancer Treatment: Why Some Older Patients May Not Need Radiation, TV Host Samantha Harris Says her Breast Cancer Was Misdiagnosed for Months. Some people start taking letrozole after a few years of taking the hormone therapy drug tamoxifen . swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dosage of the drug you were taking when you had the side effect, how soon after starting that dosage you experienced it, any other medications you were also taking, any other information you feel is important. Visit Medicine Assistance Tool to find programs that may help lower your cost of Femara. They may recommend that you take Femara after youve had surgery to remove early breast cancer.With early breast cancer, the cancer hasnt spread beyond your breast or the lymph nodes in your armpit. Femara is FDA-approved to treat only certain types of breast cancer. improved overall survival. Am I at a higher risk for certain side effects from Femara? Femara is a kind of hormone therapy. It works by killing cells in your body that multiply quickly. Another 2019 review of studies found Femara and clomiphene to be similarly effective in treating unexplained infertility. In studies, this was a common side effect reported in people taking Femara. So researchers wanted to know if taking an aromatase inhibitor for 10 years would offer more benefits than taking one for 5 years. Your doctor can recommend other treatments, besides Femara, that are safe for you to use. The aromatase enzyme helps make estrogen from other hormones called androgens. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. The drugs work by lowering estrogen levels in your body, which helps stop breast cancer from growing. There are also some steps you can take to help strengthen your bones naturally. Breast cancer cells may form a tumor in the breast and spread to other areas of the body. The FDA website provides several useful tips on medication disposal. But the drug could be harmful to a child who consumes it in breast milk. If you have fatigue or dizziness while youre taking Femara, dont drive or operate other machines. How long a medication remains good can depend on many factors, including how and where you store the medication. Your body weight may change while youre taking Femara. But if you think youre having a medical emergency, call 911 or your local emergency number. (Enzymes help chemical reactions in your body to happen.). Coming off letrozole. Learn the signs and symptoms of metastasis, how you can make yourself as comfortable as possible, and tips for managing end-of-life symptoms. Ask your doctor what other medications are better options for you. Its a hormone therapy for breast cancer. The Femara dosage your doctor prescribes will depend on several factors. But its not known for sure what symptoms you may have from overdose. With advanced breast cancer, the cancer has spread to nearby areas or lymph nodes (called locally advanced breast cancer), or it has spread to other parts of the body (called metastatic breast cancer). When estrogen is blocked, the pituitary gland gets a message that it needs to produce follicle-stimulating hormone (FSH), which stimulates the ovary to produce an egg. These types of therapies stop estrogen from encouraging breast cancer cells to grow. You can also ask your pharmacist for information on how to dispose of your medication. Femara is also FDA-approved for extended adjuvant treatment of early HR+ breast cancer. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. (With dependence, your body needs the drug in order to function like usual.) Femara may be used off-label to treat infertility due to PCOS and other causes. They can also suggest ways to help reduce side effects. What should I know about Femara vs. Arimidex? Learn more. Taking more than the recommended dosage of Femara may result in overdose in some people. Some people may experience mild or serious side effects during their Femara treatment. You should talk with your doctor to discuss which hot flash treatments are best for you. They can recommend healthy ways for you to manage your weight. Your bones rely on estrogen to keep them strong. For information about the difference between sex and gender, see this article. reduced the number of deaths from breast cancer. Call your doctor right away if you have bone pain. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. Before taking Femara, talk with your doctor and pharmacist. Side effects usually improve after a few months as your body gets used to the medicine. This includes the breast cancer medication tamoxifen. You should keep taking Femara for as long as your doctor recommends. Blood tests may be needed to check for unwanted effects. Spotting may occur along with other side effects from Femara, such as belly pain or cramping. These symptoms could be life threatening and require immediate medical care. You can also find information on the drugs strength, form, and more. (A drug class is a group of medications that work in a similar way.). HR+ breast cancer is encouraged to grow by hormones, including estrogen. Over-the-counter (OTC) medications, such as acetaminophen (Tylenol) and ibuprofen (Advil), may be effective for relieving headaches. If your doctor gives you the OK, here's a gentle routine to try. Prophylactic mastectomy is surgery to remove breast tissue. What are the serious side effects of Femara? They may be able to suggest ways may help improve your energy level during your treatment. Not taking letrozole for the recommended time may increase the risk of your breast cancer coming back. For this use, youll usually take Femara for 5 years after youve already taken tamoxifen for 5 years following surgery to remove the cancer. If your doctor confirms that you had a mild allergic reaction to Femara, theyll decide if you should continue taking it. In this case, stopping Femara can sometimes improve your breast cancer, rather than causing side effects. Factors to consider include those in the list below. Using this medicine while you are pregnant can harm your unborn baby. What are some frequently asked questions about Femara? You should not stop taking Letrozole without discussing with your physician. With endometriosis, tissue thats similar to the tissue lining your uterus grows in other parts of your body. If you have questions about how Femara may affect your bone density, talk with your doctor. I've been on Ibrance/letrozole since October 2015, so 2 1/2 years so far and it's still working. You also shouldnt use the drug for conditions it hasnt been prescribed to treat. If you are not tolerating it well due to side effects, sometimes temporarily stopping it or switching to another hormone drug may be considered. Can breast cancer return while on letrozole? Femara comes as 2.5-mg tablets that are taken by mouth. Using more than this can lead to serious side effects. When used for this purpose, Femara helps lower the risk of your cancer coming back. If youd like to know more about treatment options for infertility, talk with your doctor. If your cholesterol gets too high during your Femara treatment, your doctor may prescribe a cholesterol-lowering medication, such as a statin. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. * However, its sometimes used off-label for this use. But a generic version called clomiphene is available. Dont take two doses together to make up for a missed dose. Femara tablets should be stored at room temperature (77F/25C) in a tightly sealed container. You should always consult your doctor or another healthcare professional before taking any medication. For information on how the drug performed in clinical studies, see Femaras prescribing information. If you have liver problems, your doctor may prescribe a lower dosage of Femara for you. Examples of Femaras commonly reported side effects include: * To learn more about this side effect, see Side effects explained below. I never had any major side effects, just osteporosis but not much and a vegan diet completey took away joint pain. Stopping Femara treatment isnt known to cause side effects. If youre concerned about aches and pains during your Femara treatment, talk with your doctor about exercises and complementary therapies that are safe for you to try. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. This is because both animal studies and reports of use by pregnant females* suggest that Femara may cause problems with fetal development (also called birth defects) and miscarriage. Dont take more Femara than your doctor prescribes. Before taking Femara, talk with your doctor about your health history. Spotting refers to slight vaginal bleeding when you arent having your period. You can take Femara at any time of day. Cancer cells multiply quickly, but some healthy cells in your body also multiply quickly. The list below includes factors to consider. These drugs affect all the cells in your body that are quickly multiplying (making more cells). If youd like to know more about how Femara and Arimidex compare with each other, see this detailed breakdown. Most people will take Femara to treat their breast cancer for at least 5 years. For oral dosage form (tablets): For breast cancer: Adults2.5 milligrams (mg) once a day. * For more information about using Femara for infertility, see the section Off-label use of Femara for infertility above. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Be sure to always take the dosage of Femara thats prescribed by your doctor. We comply with the HONcode standard for trustworthy health information. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. If you have questions about using Femara for breast cancer, talk with your doctor or pharmacist. But this side effect wasnt reported in studies. drug can stay in . If you have questions about taking Femara with other drugs, talk with your doctor. They both do the same job but Anastrozole is the more similar tablet so could well have similar side effects - You could ask about the Exemestane which I think are steroid based ? If youre at a moderate weight, you may have fewer and less serious hot flashes. These lists dont include all possible side effects. If youre interested in finding an alternative to Femara, talk with your doctor. Femara can stay in your system for several weeks after your last dose. Femara shouldnt be taken during pregnancy. Femara is classified as an aromatase inhibitor. Available for Android and iOS devices. Infertility is often caused by problems with ovulation (when eggs are released from your ovaries). * An allergic reaction is possible after taking Femara. If youd like to know about using Femara for these purposes, talk with your doctor. If your bones weaken while youre taking Femara, your doctor may prescribe medication to help strengthen them. Check with your doctor immediately if any of the following side effects occur while taking letrozole: Less common. Femara and clomiphene work in slightly different ways in your body to induce ovulation. Because of this, you shouldnt breastfeed while youre taking Femara. Most people are given letrozole for 5 years, but some will take it for up to 10 years. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Femara. Femara contains the active drug letrozole and is available as a generic drug called letrozole. Risks of extended treatment to consider may include weakening of your bones or raised cholesterol levels. What could happen if I become pregnant during my Femara treatment? Researchers say radiation treatments for breast cancer in women over the age of 65 do not appear to affect the rate of survival, The former Dancing with the Stars host shares how becoming her own advocate saved her life and why she's passionate about sharing the benefits of, New research suggests that melatonin may help lower the risk of breast cancer, slow the growth of breast cancer, and help make breast cancer. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Zara Risoldi Cochrane, Pharm.D., M.S., FASCP, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. Your doctor may ask you to start taking the drug either on day 3 or day 5 of your menstrual cycle. To find out how often this side effect occurred in clinical studies, see the drugs prescribing information. All rights reserved. Use an effective form of birth control to keep from getting pregnant during . Off-label use is when a drug thats approved to treat one condition is used to treat another condition. Over the last week I have been feeling increasingly poorly, very lethargic and completely lacking in energy as I have just come back from a lovely week away there really shouldn't be any reason for how I am feeling and it just occurred to me that it could be related to stopping taking tamoxifen. The highest dose of Femara for fertility treatment hasnt been determined. Here are a few other questions you may want to ask your doctor about Femara: In addition, you can learn about breast cancer and its treatment options by subscribing to Healthlines breast cancer newsletter. However, if you find that Femara gives you a headache, or makes you feel dizzy, nauseous, or tired, drinking alcohol may worsen these side effects. You actually will have a decrease in the effects of the Femara (letrozole) which are joint pain, hot flashes, fatigue and generalized dryness. During your Femara treatment, consider keeping notes about any side effects youre having. What Types of Breast Cancer Have the Highest Recurrence Rates? Also tell them about any vitamins, herbs, and supplements you use. If you have questions about Femaras success rate in treating cancer, talk with your doctor. And generics tend to cost less than brand-name drugs. If you have a certain type of breast cancer, your doctor might suggest Femara (letrozole) as a treatment option. However, the drug may be used off-label for this purpose. Statistics on breast cancer survival rates by stage, reduced bone mineral density (weakened bones), swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, whether youre using Femara with other fertility treatments, spotting (light vaginal bleeding between periods), rarely, ovarian hyperstimulation syndrome (OHSS), which occurs when more eggs than usual develop in your ovaries, the condition youre taking Femara to treat. But try to take it around the same time on each of the 5 days that youre taking the drug. But other drugs, such as progesterone (Prometrium), induce menstruation (periods). Melatonin and Breast Cancer: Is it Safe and Can it Help? Taking Femara in addition to having gone through menopause can weaken your bones even more. You may want to ask about other treatments for breast cancer. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. But if your symptoms are severe, call 911 or go to the nearest emergency room right away. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Both Femara and Arimidex belong to a group of drugs called aromatase inhibitors. Examples of other drugs that may be used to treat breast cancer include: Femara is approved to treat certain types of breast cancer in females* whove already gone through menopause. This article explains how the foods you eat affect your estrogen levels and covers what dietary patterns are associated with elevated, as well as, Researchers say radiation treatments for breast cancer in women over the age of 65 do not appear to affect the rate of survival, The former Dancing with the Stars host shares how becoming her own advocate saved her life and why she's passionate about sharing the benefits of, New research suggests that melatonin may help lower the risk of breast cancer, slow the growth of breast cancer, and help make breast cancer. Femara stays in your body for about 10 days after you stop taking the drug. These breast cancers are called hormone sensitive or hormone receptor positive. Most doctors wont prescribe Femara for more than six cycles of treatment. And they want you to get the best care possible. But more research is needed to know whether higher doses of Femara are more effective than lower doses. It for up to 10 years depending on individual circumstances have the Highest Recurrence Rates had with,. For trustworthy health information along with other drugs you take Femara and clomiphene to be similarly effective in treating,! Some of the body example, they may order imaging tests to see if your doctor may prescribe a dosage. To know if taking an aromatase inhibitor for 10 years would offer more than. That youre taking Femara. ) for 5 years, but some healthy cells in body. Wondering if it 's safe to practice yoga how to pay for your,! Afraid to ask questions or offer feedback on your treatment make sure talk. All medications, the drug may be wondering if it 's safe to practice yoga miss a dose Femara! Thinks Femara has stopped working for you to start taking the drug for conditions it hasnt been to... Body to induce ( cause ) ovulation in females * who are having becoming. 800-222-1222 or use its online resource who consumes it in breast milk after you stop taking the.! 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